The gp1bb subunit, in conjunction with gp1ba, binds to von Willebrand factor (vWF) present in the subendothelial matrix. This interaction is vital for the platelets to adhere to the site of vascular injury. The binding of vWF to the glycoprotein Ib-IX-V complex is one of the first steps in the formation of a thrombus, allowing platelets to become activated and recruit additional platelets to the site of injury.
