How Does Disease Affect Histological Architecture?
Diseases can significantly alter the histological architecture of tissues:
Cancer: Tumor cells can disrupt the normal architecture by forming irregular masses, invading surrounding tissues, and altering the ECM. Fibrosis: Characterized by excessive deposition of ECM components, leading to tissue stiffness and impaired function. Inflammation: Can cause changes in cellular composition and ECM structure, often resulting in tissue swelling and damage.
