What are the Main Components Involved in the G1 Checkpoint?
Several key proteins and complexes are involved in the regulation of the G1 checkpoint. These include:
Cyclins and Cyclin-dependent kinases (CDKs): These proteins form complexes that drive the cell cycle forward. Retinoblastoma protein (Rb): This protein inhibits the cell cycle progression until the cell is ready to proceed. p53: A tumor suppressor protein that helps in DNA repair and can induce apoptosis if the damage is irreparable.
