clathrin mediated endocytosis

How Does Clathrin-Mediated Endocytosis Work?

CME begins with the recruitment of clathrin to specific regions of the plasma membrane via adaptor proteins such as AP2. These adaptor proteins recognize and bind to specific motifs on cargo molecules. The clathrin triskelions then assemble into a coated pit. Once the pit is fully formed and invaginated, the GTPase dynamin wraps around the neck of the budding vesicle, facilitating its scission from the membrane. The vesicle then loses its clathrin coat before fusing with early endosomes for sorting.

Frequently asked queries:

Partnered Content Networks

Relevant Topics