Senolytic agents are designed to target and induce apoptosis in senescent cells while sparing normal, healthy cells. These agents often work by disrupting the pro-survival pathways that senescent cells rely on. For example, some senolytics inhibit the Bcl-2 family of proteins, which are crucial for cell survival. Other agents might target specific senescence markers or signaling pathways such as the PI3K/AKT pathway.
