Pathogens can cause a variety of changes in tissues, often seen through histological techniques. For instance, viruses like the Ebola virus cause hemorrhagic fever, leading to significant tissue necrosis and bleeding. Bacteria like Mycobacterium tuberculosis can induce granulomatous inflammation, characterized by the formation of granulomas. Fungi, such as Cryptococcus neoformans, can lead to distinctive mucinous capsules in tissues.