How Do Hyperplasia and Hypertrophy Differ Histologically?
Histologically, hyperplasia and hypertrophy can be distinguished based on the changes observed in the tissue architecture. In hyperplasia, there is an increase in the number of cells, which results in a denser tissue with more nuclei. In contrast, hypertrophy is characterized by an increase in cell size, leading to larger cells with more abundant cytoplasm and organelles. For example, in hypertrophied cardiac muscle fibers, the cells appear larger with more prominent nuclei and increased amounts of contractile proteins.
