Both hyperplasia and hypertrophy can be reversible if the underlying stimulus is removed. In hyperplasia, the removal of the stimulating factor, such as hormonal imbalance or chronic irritation, can lead to a reduction in cell number and a return to normal tissue architecture. In hypertrophy, the cessation of the increased functional demand, such as reduced physical activity or control of hypertension, can lead to a decrease in cell size and a return to the normal state.
