How Do Histological Changes Contribute to Chronic Pain?
Chronic pain often involves long-term histological changes in both peripheral and central nervous systems. In the periphery, chronic pain can lead to the proliferation of nociceptors and changes in their sensitivity. In the central nervous system, repeated pain signals can cause central sensitization, where the spinal cord and brain become more responsive to pain stimuli. This can result in persistent pain even in the absence of ongoing tissue damage.
