How Do Extracellular Matrix Components Affect Growth Inhibition?
The extracellular matrix (ECM) plays a crucial role in regulating cell behavior, including growth inhibition. Components of the ECM, such as collagen, laminin, and fibronectin, interact with cell surface receptors like integrins. These interactions can activate signaling pathways that lead to changes in gene expression, ultimately inhibiting cell proliferation. For instance, the binding of ECM proteins to integrins can activate the signal transduction pathways that promote cell cycle arrest.
