How do eIF1 and eIF1A contribute to translation initiation?
eIF1 is responsible for promoting the formation of an open complex, allowing the scanning of mRNA for the correct start codon. It prevents premature tRNA binding and ensures the fidelity of start codon selection. On the other hand, eIF1A stabilizes the binding of eIF1 and other initiation factors to the 40S ribosomal subunit, facilitating the assembly of the PIC and enhancing the accuracy of start codon recognition.
