Are there any diseases associated with dysregulation of eIF1 and eIF1A?
Mutations or alterations in the expression of eIF1 or eIF1A can lead to various diseases. For instance, certain cancers have been linked to overexpression or mutations in these factors, which can disrupt normal protein synthesis and contribute to oncogenesis. Additionally, defects in translation initiation can be involved in neurodegenerative disorders and other conditions related to protein misfolding.
