How Do EGFR Mutations Affect Histological Features?
EGFR mutations can influence the histological appearance of tumors. For instance, NSCLC with EGFR mutations often presents as adenocarcinoma with specific histological patterns, such as lepidic growth. These tumors tend to have a glandular architecture and can show mucin production. Recognizing these patterns helps pathologists predict the presence of EGFR mutations, guiding further genetic testing.
