How Can DNase I Footprinting Complement Other Techniques?
DNase I footprinting can be used alongside other methods such as ChIP-Seq (Chromatin Immunoprecipitation Sequencing) and EMSA (Electrophoretic Mobility Shift Assay) to provide a more comprehensive understanding of protein-DNA interactions. While ChIP-Seq offers genome-wide mapping of binding sites, DNase I footprinting provides fine-resolution mapping of specific regions.