The function of each zone in the adrenal cortex is regulated by specific hormonal signals. The zona glomerulosa is primarily regulated by the renin-angiotensin-aldosterone system (RAAS), which responds to changes in blood pressure and electrolyte balance. The zona fasciculata is regulated by adrenocorticotropic hormone (ACTH) from the anterior pituitary gland, which is released in response to stress. The zona reticularis is also influenced by ACTH, although its regulation is less well understood compared to the other zones.
