How are NMDA Receptors Involved in Neurodegenerative Diseases?
NMDA receptors are implicated in various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Overactivation of NMDARs can lead to excitotoxicity, a process where excessive Ca²⁺ influx causes neuronal damage and cell death. This excitotoxicity is a significant factor in the pathophysiology of these diseases. Histological examinations often reveal altered expression and distribution of NMDA receptors in affected brain regions.
