DIC can be triggered by various underlying conditions that cause widespread activation of the coagulation system. Some of the common causes include:
1. Sepsis: Severe bacterial infections can lead to the release of endotoxins that activate the clotting cascade. 2. Trauma: Extensive physical injury can release tissue factor, which initiates coagulation. 3. Malignancies: Certain cancers, particularly those of the pancreas, prostate, and lungs, can produce pro-coagulant substances. 4. Obstetric Complications: Conditions like placental abruption and amniotic fluid embolism are known triggers. 5. Major Surgery: Extensive surgical procedures can also lead to DIC.
