matrix metalloproteinases

How are MMPs Classified?

MMPs are classified based on their substrate specificity and domain organization. Some of the main categories include:
- Collagenases: Degrade fibrillar collagens (e.g., MMP-1, MMP-8).
- Gelatinases: Degrade gelatin and type IV collagen (e.g., MMP-2, MMP-9).
- Stromelysins: Degrade a variety of ECM proteins (e.g., MMP-3, MMP-10).
- Membrane-type MMPs (MT-MMPs): Anchored to the cell membrane (e.g., MMP-14).

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