How are Lysosomal Enzymes Synthesized and Targeted to Lysosomes?
Lysosomal enzymes are synthesized in the rough endoplasmic reticulum (ER) and are post-translationally modified in the Golgi apparatus. They are tagged with mannose-6-phosphate (M6P) residues, which are recognized by M6P receptors in the trans-Golgi network. This recognition ensures that these enzymes are packaged into vesicles and transported to lysosomes.
