Histopathological changes are detected through various techniques:
Biopsy: The removal of a small tissue sample for examination under a microscope. Biopsies are commonly used to diagnose cancers and other diseases.
Staining: The application of dyes to tissues to highlight specific structures or components. Common stains include Hematoxylin and Eosin (H&E), which differentiate cellular components and extracellular matrix.
Immunohistochemistry: A technique that uses antibodies to detect specific antigens in tissues. It is particularly useful for identifying proteins associated with diseases like cancer.
Electron Microscopy: Provides detailed images of cellular ultrastructure, allowing for the identification of subtle changes not visible with light microscopy.
