The diagnosis of gastrinomas involves multiple steps: 1. Clinical Evaluation - Symptoms like abdominal pain, diarrhea, and gastroesophageal reflux are evaluated. 2. Biochemical Tests - Elevated levels of serum gastrin can indicate the presence of a gastrinoma. 3. Imaging Studies - Techniques such as CT scans, MRI, and somatostatin receptor scintigraphy (SRS) help localize the tumor. 4. Histological Examination - A biopsy followed by histological and immunohistochemical analysis confirms the diagnosis.
