Coagulation tests are typically performed using a blood sample. The sample is mixed with various reagents to initiate clotting, and the time taken for clot formation is measured. The specific method depends on the type of test being conducted:
1. Prothrombin Time (PT): Blood is mixed with tissue factor and calcium to initiate the extrinsic pathway. 2. Activated Partial Thromboplastin Time (aPTT): Blood is mixed with an activator and calcium to initiate the intrinsic pathway. 3. Thrombin Time (TT): Blood is mixed with thrombin to directly measure fibrinogen conversion. 4. Platelet Function Tests: Various methods, including aggregometry and flow cytometry, are used to assess platelet function.
