CDKs are regulated through multiple mechanisms to ensure proper cell cycle progression:
Binding to cyclins: Specific cyclins are synthesized and degraded at different stages of the cell cycle, which activate or deactivate CDKs accordingly. Phosphorylation: CDKs can be activated or inhibited by phosphorylation at specific sites by other kinases and phosphatases. CDK Inhibitors (CKIs): Proteins such as p21 and p27 can bind to CDKs and inhibit their activity.
