Can Stellate Cells be Targeted for Therapeutic Interventions?

Given their significant role in fibrosis and tissue remodeling, stellate cells represent a potential therapeutic target. In liver disease, strategies to inhibit the activation of hepatic stellate cells or promote their apoptosis are being explored. Similarly, targeting pancreatic stellate cells to reduce fibrosis and improve the efficacy of cancer treatments is an area of active research. In the central nervous system, modulating astrocyte activity may offer therapeutic benefits for neurodegenerative and neuroinflammatory diseases.