Given its central role in heart development, NKX2.5 is a potential target for therapeutic interventions. Research is ongoing to develop strategies that can modulate NKX2.5 activity to treat congenital heart diseases. For instance, gene therapy approaches are being explored to correct NKX2.5 mutations or to enhance its expression in failing hearts. Additionally, small molecules that can influence the activity of NKX2.5 or its downstream targets are of significant interest in cardiac regenerative medicine.
