Yes, hormonal changes significantly influence bone histology. Parathyroid hormone (PTH) and calcitonin are major regulators of bone metabolism. PTH increases osteoclast activity, leading to bone resorption, while calcitonin inhibits it. Additionally, estrogen and testosterone play vital roles in maintaining bone density. For instance, decreased estrogen levels during menopause can lead to osteoporosis, characterized by reduced bone mass and altered bone microarchitecture.
