What are the Challenges in Working with Histological Samples?

Several challenges can arise when working with histological samples:
1. Artifact Formation: Improper handling or preparation can introduce artifacts that may obscure or mimic pathological findings.
2. Tissue Preservation: Ensuring that samples are properly fixed and stored to prevent degradation over time.
3. Sample Size: Obtaining a sufficiently large and representative sample can be difficult, particularly in needle biopsies.
4. Interpreting Results: Variability in staining and tissue architecture can make interpretation challenging, requiring expertise and experience.