Can Cox Negative Fibers be Found in Normal Individuals?
While COX negative fibers are primarily associated with pathological conditions, a small number of these fibers can also be found in healthy, aging individuals. The proportion of COX negative fibers tends to increase with age, reflecting the cumulative effect of mitochondrial mutations over time. However, the presence of a large number of COX negative fibers is typically indicative of an underlying mitochondrial disorder.
