Are There Any Disorders Associated with OPC Dysfunction?

Yes, several neurological disorders are associated with OPC dysfunction. Multiple sclerosis is one of the most well-known conditions, characterized by the loss of myelin and failure of remyelination. In this disease, the inability of OPCs to differentiate into functional oligodendrocytes results in chronic demyelination and neurodegeneration. Other disorders, such as leukodystrophies, are also linked to defects in OPCs and myelination processes.