Are there any adverse histological effects of SSRIs?
While SSRIs are generally considered safe, long-term use can potentially lead to histological alterations in various tissues. For instance, chronic SSRI administration may result in changes to gastrointestinal tract tissues, given the high concentration of serotonin receptors in the gut. Some studies have noted alterations in the morphology of gastrointestinal epithelial cells and smooth muscle cells.
