How do CFTR modulators work at the cellular level?
CFTR modulators work at the cellular level by targeting the defective CFTR protein. There are different classes of modulators:
- Potentiators: Enhance the activity of CFTR channels at the cell surface. - Correctors: Aid in the proper folding and trafficking of CFTR protein to the cell membrane. - Amplifiers: Increase the overall production of CFTR protein.
These modulators help to restore chloride transport and improve the hydration of mucus, thereby alleviating some of the symptoms associated with CF.
