cyp2j2 gene - Histology

What is the cyp2j2 Gene?

The cyp2j2 gene encodes a member of the cytochrome P450 superfamily of enzymes. These enzymes are monooxygenases which play a crucial role in the metabolism of endogenous and exogenous compounds. Specifically, CYP2J2 is involved in the metabolism of arachidonic acid to epoxyeicosatrienoic acids (EETs), which have significant biological functions.

Location and Expression of cyp2j2

The cyp2j2 gene is located on chromosome 1 in humans. Expression of CYP2J2 is found in various tissues but is particularly prominent in the heart, liver, and gastrointestinal tract. This widespread expression indicates its broad role in physiological processes.

Function in the Cardiovascular System

In the cardiovascular system, CYP2J2-derived EETs are involved in vasodilation, anti-inflammatory responses, and protection against ischemia-reperfusion injury. These functions are crucial for maintaining cardiovascular homeostasis and protecting against cardiovascular diseases.

Role in the Liver

The liver expresses CYP2J2, where it contributes to drug metabolism and detoxification. This enzyme helps in the oxidation of various substrates, thereby facilitating their excretion from the body.

Histological Techniques to Study cyp2j2

Several histological techniques can be employed to study the expression and localization of CYP2J2 in tissues. Immunohistochemistry (IHC) is commonly used to visualize CYP2J2 distribution, while in situ hybridization can detect cyp2j2 mRNA. Western blotting and RT-PCR are also utilized to quantify CYP2J2 protein and mRNA levels, respectively.

Clinical Implications

Alterations in cyp2j2 gene expression or function have been linked to various diseases. Overexpression of CYP2J2 has been associated with certain cancers, while reduced activity has been implicated in cardiovascular diseases. Understanding the expression patterns and functions of CYP2J2 can aid in the development of therapeutic strategies targeting these conditions.

Future Directions

Future research should focus on the detailed mechanisms by which CYP2J2-derived EETs exert their protective effects. Additionally, the development of specific inhibitors or activators of CYP2J2 could provide novel therapeutic avenues for treating diseases associated with dysregulated CYP2J2 activity.

Relevant Publications

Metabolomic analysis of vascular cognitive impairment due to hepatocellular carcinoma.

Issue Release: 2023

Risk Factors for Rivaroxaban-Related Bleeding Events-Possible Role of Pharmacogenetics: Case Series.

Issue Release: 2023

Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine .

Issue Release: 2023

MiR-3646 accelerates inflammatory response of Ang II-induced hVSMCs via CYP2J2/EETs axis in hypertension model.

Issue Release: 2023

Pharmacogenetic Variation in Neanderthals and Denisovans and Implications for Human Health and Response to Medications.

Issue Release: 2023

Identification of Biomarkers Associated with Heart Failure Caused by Idiopathic Dilated Cardiomyopathy Using WGCNA and Machine Learning Algorithms.

Issue Release: 2023

Comparative analysis of whole-transcriptome RNA expression of lung tissue of Chinese soft-shell turtle infected by Trionyx sinensis Hemorrhagic Syndrome Virus.

Issue Release: 2023

Cytochrome Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes.

Issue Release: 2022

Crosstalk between adenosine receptors and CYP450-derived oxylipins in the modulation of cardiovascular, including coronary reactive hyperemic response.

Issue Release: 2022

CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.

Issue Release: 2022

Screening of Lipid Metabolism-Related Gene Diagnostic Signature for Patients With Dilated Cardiomyopathy.

Issue Release: 2022

Corrigendum to \"ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia\" [Materials Today Bio 13(2022) 100192].

Issue Release: 2022

Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome.

Issue Release: 2022

ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia.

Issue Release: 2021

Comprehensive transcriptome-wide analysis of spliceopathy correction of myotonic dystrophy using CRISPR-Cas9 in iPSCs-derived cardiomyocytes.

Issue Release: 2021

CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.

Issue Release: 2021

Cytochrome P450 2J2 inhibits the proliferation and angiogenesis of retinal vascular endothelial cells by regulating the Notch signaling pathway in a hypoxia-induced retinopathy model.

Issue Release: 2021

CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.

Issue Release: 2021

A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease.

Issue Release: 2021

Integrative transcriptome analysis and discovery of signaling pathways involved in the protective effects of curcumin against oxidative stress in tilapia hepatocytes.

Issue Release: 2020

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