BPH - Histology

What is Benign Prostatic Hyperplasia (BPH)?

Benign Prostatic Hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland, which is common in older men. This condition can lead to urinary difficulties due to the compression of the urethra and is often associated with lower urinary tract symptoms (LUTS).

Histological Features of BPH

Histologically, BPH is characterized by an increase in the number of both stromal and epithelial cells in the prostate. The hyperplasia typically affects the transitional zone of the prostate, leading to the formation of nodules. These nodules can compress the urethra, causing obstruction and urinary symptoms.

What Causes BPH?

The exact cause of BPH is not fully understood, but it is believed to be related to hormonal changes associated with aging. Increased levels of dihydrotestosterone (DHT) and estrogen in older men are thought to contribute to the proliferation of prostate cells.

Histological Examination Techniques

To diagnose BPH, a biopsy of the prostate tissue is often performed. The tissue samples are then examined under a microscope using hematoxylin and eosin (H&E) staining. This allows pathologists to observe the cellular architecture and identify characteristic features of BPH, such as glandular and stromal hyperplasia.

Differences Between BPH and Prostate Cancer

Although BPH and prostate cancer can present with similar symptoms, they are distinct conditions. Histologically, BPH is characterized by a benign proliferation of cells, whereas prostate cancer involves the uncontrolled growth of malignant cells. A key histological feature distinguishing prostate cancer is the presence of atypical cells and invasion into surrounding tissues.

Treatment Options

Treatment for BPH depends on the severity of symptoms. Options include medication to relax the prostate muscles or shrink the gland, minimally invasive procedures, and surgery. Transurethral resection of the prostate (TURP) is a common surgical procedure where excess prostate tissue is removed to alleviate symptoms.

Research and Future Directions

Ongoing research aims to better understand the cellular and molecular mechanisms underlying BPH. Advances in genomics and proteomics are providing new insights into the pathogenesis of BPH, potentially leading to more effective treatments and diagnostic tools in the future.

Relevant Publications

Di-(2-ethylhexyl) phthalate promotes benign prostatic hyperplasia through KIF11-Wnt/β-catenin signaling pathway.

Issue Release: 2024

Effects of imidacloprid combined with validamycin on the population fitness and symbiotic of Nilaparvata lugens (Hemiptera: Delphacidae).

Issue Release: 2024

Integrated network pharmacology and serum metabonomics analysis to explore the potential mechanism of Anemarrhena asphodeloides Bunge-Phellodendron chinense Schneid herb pair in the treatment of benign prostatic hyperplasia.

Issue Release: 2024

Loneliness, functional disability and lower urinary tract symptoms suggestive of benign prostatic hyperplasia in aging men: Insights from the China health and retirement longitudinal study.

Issue Release: 2024

Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study.

Issue Release: 2024

Retzius sparing robot-assisted radical prostatectomy: optimizing functional results.

Issue Release: 2024

Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro exposure.

Issue Release: 2024

Analysis of the roles of MAD proteins in the wing dimorphism of Nilaparvata lugens.

Issue Release: 2024

Prostate Artery Embolization (PAE) with Small Beads for the Treatment of Benign Prostatic Hyperplasia (BPH).

Issue Release: 2024

Predicting the Diagnosis of Prostate Cancer with a Novel Blood-Based Biomarker: Comparison of Its Performance with Prostate-Specific Antigen.

Issue Release: 2024

Comparing the incidence of postoperative painful bladder spasm between malecot catheter and 3-way Foley catheter: a clinical trial.

Issue Release: 2024

Risk factors for postoperative urinary retention in patients underwent surgery for benign anorectal diseases: a nested case-control study.

Issue Release: 2024

Multi-Omics Analysis of Primary Prostate Cancer Datasets Reveals Novel Biomarkers.

Issue Release: 2024

Effect of α-blockers on Handgrip Test Response of Diastolic Blood Pressure in Hypertensive, Benign Hypertrophy of Prostate Patients in a Therapeutics Clinic, Kolkata: A Cross-sectional Study.

Issue Release: 2024

How I Do It: Holmium laser cystolitholapaxy and enucleation of the prostate for benign prostatic hyperplasia.

Issue Release: 2024

Integration of molecular breeding and multi-resistance screening for developing a promising restorer line Guihui5501 with heavy grain, good grain quality, and endurance to biotic and abiotic stresses.

Issue Release: 2024

Adherence to AUA guidelines for the work-up, medical management, surgical evaluation and treatment of BPH: Work from a quality improvement collaborative.

Issue Release: 2024

Clinical practice of the transrectal shear-wave elastography in benign prostatic hyperplasia.

Issue Release: 2024

Infiltrating lipid-rich macrophage subpopulations identified as a regulator of increasing prostate size in human benign prostatic hyperplasia.

Issue Release: 2024

Integrating spatial transcriptomics and single-cell RNA-sequencing reveals the alterations in epithelial cells during nodular formation in benign prostatic hyperplasia.

Issue Release: 2024

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