TEWL is a critical parameter for assessing the skin barrier function. A high TEWL indicates a compromised barrier, which can be a result of skin conditions such as eczema, psoriasis, or atopic dermatitis. Conversely, low TEWL values suggest a healthy, intact barrier. Understanding TEWL helps in diagnosing skin conditions, evaluating the efficacy of treatments, and in the development of skincare products.