Ensuring substrate compatibility is vital for several reasons:
Preservation of tissue morphology: An incompatible substrate can lead to the deformation or destruction of tissue architecture. Staining quality: The substrate can affect how stains interact with the tissue, potentially leading to poor visualization or misinterpretation of results. Adherence: Tissues must adhere properly to the substrate to prevent detachment during processing and analysis. Reproducibility: Compatible substrates ensure consistent results across multiple experiments.
