In histology, the study of tissues, LH2 is particularly significant because collagen is a major structural protein in the extracellular matrix of various tissues. Proper functioning of LH2 ensures the correct assembly and stability of collagen fibers, which is essential for the structural and functional integrity of connective tissues, including skin, bones, tendons, and cartilage. Abnormalities in LH2 activity can lead to connective tissue disorders.