Why is Histology Important in B Cell Malignancies?
Histology plays a crucial role in the diagnosis, classification, and management of B cell malignancies. It helps in:
- Differentiating Subtypes: Histological examination can distinguish between various subtypes of B cell malignancies, which is essential for appropriate treatment planning. - Prognostic Information: Certain histological features can provide prognostic information. For example, the presence of specific genetic mutations or the extent of bone marrow infiltration can affect the prognosis. - Guiding Treatment: Histological findings guide the selection of targeted therapies. For instance, the presence of CD20 expression in B cells makes patients eligible for treatment with Rituximab, an anti-CD20 monoclonal antibody.
