The importance of COPI in cellular processes cannot be overstated. It ensures that enzymes and other proteins are correctly sorted and delivered to their proper destinations, which is crucial for maintaining cellular homeostasis. COPI-mediated transport is particularly vital for the ER-Golgi intermediate compartment (ERGIC) and for recycling proteins back to the ER. This retrograde transport is essential for the retrieval of ER-resident proteins and for maintaining the lipid composition of the ER membrane.
