Traditional histological techniques, such as H&E staining, provide valuable insights but have their limitations. Multimodal approaches overcome these limitations by integrating various methods like immunohistochemistry (IHC), in situ hybridization (ISH), and advanced imaging techniques like confocal microscopy and multiphoton microscopy. This comprehensive approach enhances the depth and breadth of tissue analysis, leading to better diagnostic accuracy and more insightful research findings.