Which Techniques are Used in Histology for Drug Screening?
Several histological techniques are employed in drug screening, including:
1. Histological Staining: Techniques like Hematoxylin and Eosin (H&E) staining provide general tissue architecture visualization. 2. Immunohistochemistry: This technique uses antibodies to detect specific proteins and can show how drugs affect the expression of target molecules. 3. In Situ Hybridization: Allows for the localization of specific nucleic acid sequences within tissue sections, useful for studying gene expression changes due to drug treatment. 4. Electron Microscopy: Provides detailed ultrastructural information about cellular and subcellular changes induced by drugs.
