DC primarily affects rapidly dividing cells, leading to notable histological changes in:
- Epidermal Keratinocytes: These cells may show abnormal differentiation, leading to the characteristic skin changes. - Hematopoietic Stem Cells: These cells are crucial for blood cell production, and their depletion leads to bone marrow failure. - Nail Matrix Cells: Abnormalities in these cells result in the dystrophic changes observed in nails.
