L1CAM is predominantly expressed in the nervous system, including the brain and spinal cord. It is found on the surface of neurons, glial cells, and some epithelial cells. Its expression is particularly high during embryonic development but continues to be present in the adult brain. Research has shown that L1CAM is also expressed in certain types of cancers, such as ovarian and endometrial cancers, where it is often associated with poor prognosis.
