damage associated molecular patterns (damps)

What types of molecules are considered DAMPs?

DAMPs encompass a wide variety of molecules, including High Mobility Group Box 1 (HMGB1), Heat Shock Proteins (HSPs), Adenosine Triphosphate (ATP), and DNA fragments. These molecules are normally contained within cells but are released into the extracellular space upon cellular injury or necrosis.

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