The dermis is populated by several cell types, each contributing to the skin's function:
Fibroblasts: These are the principal cells of the dermis, responsible for synthesizing collagen, elastin, and the glycosaminoglycans that constitute the extracellular matrix. Macrophages: These immune cells play a role in phagocytosis and are crucial for the skin's defense mechanisms. Mast Cells: These cells release histamine and other mediators involved in inflammatory responses and allergic reactions. Adipocytes: Though more abundant in the subcutaneous layer, some adipocytes can be found in the deeper regions of the dermis, providing insulation and energy storage.
