Dysregulation of ATP Citrate Lyase is linked to several diseases. For example, overexpression of ACLY is associated with cancer, as it supports the increased lipid synthesis needed for tumor growth. Additionally, ACLY is implicated in metabolic disorders such as obesity and diabetes, where altered lipid metabolism plays a central role. Understanding the histological patterns of ACLY expression can aid in diagnosing and developing therapeutic strategies for these conditions.
