macropinocytosis

What Regulates Macropinocytosis?


Macropinocytosis is regulated by various signal transduction pathways. Key regulators include phosphoinositide 3-kinase (PI3K), Rho GTPases, and growth factors such as epidermal growth factor (EGF). These molecules coordinate the actin cytoskeleton dynamics and membrane ruffling necessary for macropinocytosis. Dysregulation of these pathways can lead to pathological conditions, including cancer.

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