Keratogenesis is regulated by a multitude of molecular signals including growth factors, cytokines, and transcription factors. Key players include: - Transforming Growth Factor-β (TGF-β): Regulates cell proliferation and differentiation. - Notch Signaling Pathway: Influences keratinocyte differentiation and cell fate decisions. - p63: A transcription factor crucial for the maintenance of stem cells and initiation of keratinocyte differentiation. - AP1 Transcription Factors: Regulate gene expression related to keratinocyte proliferation and differentiation.
