Lipid rafts are typically small, ranging from 10 to 200 nanometers in size. They are enriched in cholesterol and sphingolipids, which confer a more rigid and ordered structure compared to the more fluid phospholipid bilayer. Proteins associated with lipid rafts often have lipid modifications, such as GPI anchors or fatty acid chains, that help them associate with these domains. The raft regions can coalesce to form larger platforms, facilitating the clustering of signaling molecules.
