amyloid beta (aβ) peptides

What is the Significance of Aβ42 in Alzheimer's Disease?

Aβ42 is more hydrophobic and prone to aggregation compared to Aβ40. It is the predominant species found in amyloid plaques. The higher propensity of Aβ42 to form oligomers and fibrils makes it more pathogenic, contributing significantly to the neurotoxicity observed in Alzheimer's disease.

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