Abnormal VEGF expression is associated with various diseases. Overexpression of VEGF is observed in many cancers, contributing to tumor growth and metastasis by promoting the formation of new blood vessels that supply nutrients to the tumor. In contrast, insufficient VEGF activity can result in ischemic diseases, where tissues do not receive adequate blood supply. Histological analysis can identify aberrant VEGF expression, aiding in the diagnosis and treatment planning of such conditions.
